Northington is obsessed with the myth of Quetzar, a Pokémon of incredible power that was was said to bring advancements to the native people in ancient times. The player, named either Simon or Sofia by default, has a friendly rival as well as a more acerbic rival who steals the friendly rival's starter Pokémon. Despite the general warmth of these areas, the town the player starts in is covered in snow.

It features a conflict between two villainous teams based on real-life inhabitants of these areas throughout history, such as the Aztec Empire and the Spanish conquistadors. Like many official regions in the Pokémon series, Urobos is based on a real-life region: Central and South America. Pokemon Sage takes place in a fictional region called Urobos.